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OCR: ann (1960) It had been known from the work of Mo at extracts and of Campbell and co-workers (1964) t ally active of hypothalamic tissue contain a biologi se of substance capable of stimulating the rele ary. This gonadotrophic hormones from the pitu mi of material was isolated from the hypotha. stockyard animals, and the structure was e TRH, the elucidated by Schally's group in 1971. Lil finally amide. A amino terminal of GnRH is a substitute a number terminal amide group is characteristic o ing ADH, of other small peptide hormones, incluc n; in all of oxytocin, calcitonin, gastrin, and glucage RH), the activity. these hormones (including TRH and Gr amide group is needed for full hormon